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What's more trustworthy than a diet built by experts from the Mayo Clinic? Created by doctors, nutritionists, and all-star chefs, the plan has a few phases: In the first, you should lose 6 to 10 pounds in two weeks. After that, you can expect to lose 1 to 2 pounds a week until you reach your goal weight. You're also given plenty of resources and advice to help you keep the weight off.